Consistently with this model, pharmacological inhibition of each of PGRMC1 by AG-205 or ERα by fulvestrant annulled the stimulatory effect of DYD and significantly diminished the same for NET, substantiating the assumption that both PGRMC1 and ERα essentially contribute to the propagation of progestin signals in breast cancer. This evidence concerns the gene PGRMC1 and breast carcinoma.