Interestingly, in a recent publication, Teakel and coauthors identified PHBs as PGRMC1 interaction partners in the pancreatic cancer cell line MIA PaCa-2 independently of progestin treatment [33], pointing towards an implication of PGRMC1 in PHB1/PHB2- function that is not limited to breast cancer or progestin stimulation, which deserves further investigation. Here, PHB2 is linked to familial pancreatic carcinoma.