Inhibition of Rab27a led to a reduction in primary tumor growth and the number of lung metastases in a 4T1 cell (metastatic cell line) xenograft but not in a TS/A (non-metastatic) xenograft model, indicating a possible therapeutic use of Rab27 inhibition for reducing metastases [282]. The gene discussed is RAB27A; the disease is neoplasm.