Regarding prognosis, worse overall and/or disease-free survival in HNSCC were associated with promoter hypermethylation of KL [130], HIN1 [131], RASSF1A/RASSF2 [131], MGMT [95,119,132,133], DAPK [119], MINT31 [114], p16INK4A, and p14ARF [134]. The gene discussed is MGMT; the disease is head and neck squamous cell carcinoma.