In addition to this work, several groups have demonstrated that CCL21 administration increases the frequency of TILs: Yamano et al. [75] used CCL21 as an adjuvant to promote the effect of a melanoma DNA vaccine, and Chen et al. [76] used an adenovirus vector expressing CCL21 in combination with paclitaxel and demonstrated that the combination was better than either treatment alone. This evidence concerns the gene CCL21 and melanoma.