Chemokine expression also correlates with prognosis; the expression of CXCR3 by melanoma cells is associated with a poorer prognosis and increased chance of metastasis [48], whereas CCL27 expression in the supra-tumoral dermis is associated with longer progression-free survival, perhaps due to the recruitment of CCR10+ lymphocytes [112]. The gene discussed is CXCR3; the disease is melanoma.