Aside from its direct effect on melanoma cells, CXCL8, along with other ligands of CXCR1 and CXCR2, namely CXCL1-3 and CXCL5-7, recruit innate cells, most notably neutrophils, which express the receptors CXCR1 and CXCR2 and are the “first responders” to tissue injury and damage [33]. The gene discussed is CXCL5; the disease is melanoma.