The contradictory results to Simonetti et al.’s work demonstrate the complex nature of chemokine pathways; CCR10 expression by melanoma cells appears to be associated with a poorer prognosis due to signalling through CCR10 enabling the evasion of apoptosis [113], whereas the expression of its ligand CCL27 likely promotes the recruitment of CCR10+ effector T cells [112], underscoring the context dependence of chemokine functions. Here, CCL27 is linked to melanoma.