Routinely, BNIP3 modulates mitophagy to remove dysfunctional mitochondria; in animal models of breast cancers, the absence of this protein favors the increase of ROS production, which favors the oncogenic effect of hypoxia inducible factor 1 subunit alpha (HIF1α) under hypoxia in terms of increased angiogenesis and malignances progression [159]. The gene discussed is BNIP3; the disease is breast carcinoma.