Different notions support the possibility that mitophagy is a protective mechanism used by cancer cells to escape from cell death and identified alteration of the activity of numerous mitophagy partners (such as PINK1, Parkin, BNIP3L, NIX, and FUNDC1) in several cancer types, including glioblastoma, breast cancer, hepatocellular carcinoma, acute myeloid leukemia, and prostate cancer. The gene discussed is BNIP3L; the disease is hepatocellular carcinoma.