Tumor-secreted GM-CSF, CXCL12, and CCL2 attract monocytes to the TME and drive their differentiation into M2 TAMs, which then promote angiogenesis through secretion of Matrix Metalloproteinase 9 (MMP9) and Vascular Endothelial Growth Factor A (VEGF-A) [23,24,25,26,27,28,29]. This evidence concerns the gene CXCL12 and neoplasm.