Trichostatin A and SAHA (broad-spectrum HDAC inhibitors) and Tubastatin A (HDAC6 specific inhibitor) also protects against cisplatin nephrotoxicity in kidneys through AMPK-mTOR pathways but sensitizes cancer cells to cisplatin cytotoxicity by enhancing DNA damage [113,114,160,161,162]. This evidence concerns the gene MTOR and cancer.