AKT1 and acute kidney injury: For example, p53 may activate autophagy through the inhibition of mTORC1 by AMPK [110] or miR-199a-3p [111], while activation of protein kinase Cδ (PKCδ) in cisplatin AKI inhibits autophagy through the AKT/mTORC1/ULK1 pathway [112].