A study on plasma samples from 34 HCC patients demonstrated that the low expression of DNASE1L3 in HCC coincides with a reduction of many of the DNASE1L3-associated motifs (e.g., CCCA, CCAG, and CCTG), and an increase in other motifs in these patients (e.g., TAAA, AAAA, and TTTT) [67]. The gene discussed is DNASE1L3; the disease is hepatocellular carcinoma.