In AML, unlike in lymphoid malignancies, BCL-2 gene is not rearranged, neither is it always overexpressed, but, surprisingly, this does not precluded BH3-mimetic’s efficacy, illustrating the concept of non-oncogene addiction, by which a cancer cell becomes dependent on a normal cell function [25,26]. The gene discussed is BCL2; the disease is acute myeloid leukemia.