The results indicated that high expression of KLF10, APBB2, ACTN1, AREG, MT2A, PTPN12, and PTHLH was associated with low survival in HPV−unrelated HNSCC (Figure 5A–G), whereas high expression of SLC25A39 and GJB2 was associated with poor survival only in HPV+ HNSCC (Figure 5H,I). Here, ACTN1 is linked to head and neck squamous cell carcinoma.