Mutations of ASXL1, IDH1/2, RUNX1, SRSF2, TET2, TP53 and the RAS family genes, are found in AML secondary to MPN and in MPN gaining MDS-features, e.g., TET2 and SRSF2 being linked with emergent monocytosis in MPN, and SF3B1 with emergent ring sideroblasts [17,20,23,24,25,26,27,28,29,30,31]. The gene discussed is TP53; the disease is myelodysplastic syndrome.