Grabovska and colleagues [21] used MethylCIBERSORT to recapitulate the tumor microenvironment of over 6000 primarily pediatric CNS tumors by interrogating 12 broad cell types, namely B cells, CD4+ T cells, CD8+ T cells, CD4+/FOXP3+ Treg, NK cells, monocytes, neutrophils, eosinophils, endothelial cells, glial cells, neurons and cancer cells [21]. This evidence concerns the gene CD4 and cancer.