Importantly, the partial silencing of CD44 in EO771 tumor cells reduced the inhibitory effect of recombinant Eno1 proteins on the MTT-based viability (Figure 8E,F), and partially suppressed the Eno1-driven downregulation of Lrp5, Runx2, and TGFβ in EO771 tumor cells (Figure 8G). This evidence concerns the gene RUNX2 and neoplasm.