In addition to the recombinant Eno1 proteins, the partial silencing of CD44 in EO771 tumor cells reduced the inhibitory effect of recombinant Hsp90ab1 proteins on MTT-based viability (Figure 8H), and partially suppressed the Hsp90ab1-driven downregulation of Lrp5, Runx2, and TGFβ in EO771 tumor cells (Figure 8I). The gene discussed is CD44; the disease is neoplasm.