TPO and congenital secretory chloride diarrhea 1: The goal of these practice guidelines of the Initiative Group for Central European Hepatologic Collaboration (CEHC) is to provide expert opinions and evidence-based, risk-adapted recommendations to help physicians better manage thrombocytopenia using TPO-RAs in CLD patients undergoing elective surgical interventions, reduce the need for platelet transfusions, and decrease the risk of bleeding in CLD patients with concurrent TCP before scheduled procedures.