However, numerous studies indicate that alopecia areata is associated with a systemic immune activation and the dysregulation of multiple proinflammatory cytokines, including Interleukin 1 beta (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) [5]. The gene discussed is IL1B; the disease is alopecia areata.