Diagnosis of recurrent PBC is largely reliant on histological findings, since only around 10% of recurrent PBC patients demonstrate classic symptoms of PBC, i.e., pruritis, jaundice, xerostomia, or keratoconjunctivitis sicca, etc. In order to standardize recurrent PBC, pathological features combined with the existence of AMA and elevated IgM are often adopted clinically. Here, CD40LG is linked to primary biliary cholangitis.