ERBB2 and breast cancer: A metaanalysis including 12 studies with a total of 2741 HER2+ BC tumors revealed that presence of microcalcifications is a feature that increases OR for this subtype (OR 2.45, CI 0.23–0.69), and circumscribed margins reduced OR for this subtype (OR 0.66, CI 0.43–1.02) [26].