Joachim et al. [51] showed the significant differences between the IgG antibody profiles against retinal antigens of the glaucoma groups (PEX and POAG) and controls (up- and downregulations), and the identified biomarkers included heat shock protein 27, α-enolase, actin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The gene discussed is GAPDH; the disease is open-angle glaucoma.