Patients with zygoma fracture (aHR = 1.36, 95% CI: 1.11–1.66), male sex (aHR = 0.54, 95% CI: 0.44–0.67), obesity (aHR = 2.83, 95% CI: 1.16–6.93), and depression (aHR = 2.21, 95% CI: 1.55–3.16) had a significantly higher risk of PTH. The gene discussed is PTH; the disease is obesity due to melanocortin 4 receptor deficiency.