TNFSF11 and diabetes mellitus: Poorly controlled DM generates sustained hyperglycemia, which in turn induces an increase in the inflammatory response in the periodontal tissue; this stimulates the receptor activator of nuclear factor κB (RANK)/RANK-Ligand (RANKL) axis with an increase in osteoclastogenesis and destruction of the alveolar bone, which will conclude with the clinical attachment loss, one of the PD hallmarks.