CHIT1 and early-onset autosomal dominant Alzheimer disease: CHIT1 is mainly produced by activated macrophages both in normal and inflammatory conditions [20,21]; therefore, it can be significantly increased in a wide range of diseases involving the macrophages or microglial hyperactivation, such as Gaucher disease, tuberculosis, sarcoidosis, malaria, leishmaniosis, beta thalassemia, multiple sclerosis, and Alzheimer’s disease [20,22,23,24].