Moreover, when we compared ACE with CHIT1 in our study group, we obtained a low sensitivity (26%) of ACE versus CHIT1, confirming the previous literature [8,9,10,11], and in these case series, the variation range of ACE was narrowed with respect to CHIT1, with the consequent risk of either potentially missing patients with low-activity sarcoidosis or producing false negative results. The gene discussed is CHIT1; the disease is sarcoidosis.