To our knowledge, this is the first study to evaluate the behavior of post-NSPT GCF pro-inflammatory mediators, by the ELISA method, in patients with periodontitis and chronic hepatitis C. Tasdemir et al. evaluated the effect of NSPT on serum PTX3 levels in patients with periodontitis and other systemic diseases, such as diabetes mellitus and chronic kidney disease [22]. This evidence concerns the gene PTX3 and chronic kidney disease.