Following NSPT, a significant reduction of the GCF PTX3 levels was identified, although of a lesser magnitude than in periodontitis patients with no chronic hepatitis C. This finding suggests a possible involvement of the hepatic pathology in the local inflammatory processes of periodontitis, that requires further, future research, similar to a broader approach on the role of the CRP mediator in a common periodontitis-hepatitis C scenario. This evidence concerns the gene CRP and chronic hepatitis C virus infection.