In acquired central hypothyroidism (in our study, this applied to 28/30 patients in the CH group), TSH is usually detected within the normal range (14/28 in our CH group) because of well-preserved immunoreactivity; however, the disease is characterized by a severe impairment of intrinsic bioactivity and the ability to stimulate TSH receptors. Here, TSHR is linked to Central hypothyroidism.