CRIPTO3 and cancer: In both finite/primary (human monocytes, macrophages, DC monocytes, mouse peritoneal macrophages) and cancer monocytic/macrophagic cell lines (THP-1, RAW264.7), CNF1 is able to modulate CR3 activation and its colocalization with the actin cytoskeleton (THP-1 e monocytes [60]) and downregulate CD36 transcription/expression [96], leading to a reduced phagocytic ability of nonopsonized beads and/or E. coli bacteria (THP-1, RAW264.7, mouse peritoneal macrophages [96]; THP-1, human monocytes [60]).