NCS1 and early-onset autosomal dominant Alzheimer disease: Yet, even in this case, we detected an accumulation of dense NCS-1-positive bodies in the perinuclear zone, which can represent autophagosomes or NCS-1-containing aggresomes, insoluble deposits often found in neurons in Parkinson’s disease, Alzheimer’s disease, ALS, or retinitis pigmentosa [97,98,99].