Treatment with an Shh pathway agonist in stroke mice resulted in enhanced functional recovery in locomotor and cognitive functions, as well as in neurogenesis by increasing the survival of newly born cells derived from both subventricular zone and subgranular zone neural stem cells, total DCX+ neuroblast cells, and neurons (NeuN+/YFP+) in the ischemic brain [101]. This evidence concerns the gene SHH and stroke disorder.