Pafah1b1 is the gene encoding the protein LIS1, involved in many aspects of neurogenesis, including cell differentiation, synaptic function regulation and neural migration, as well as being associated with lissencephaly, a neuronal migration disorder affecting the cerebral, hippocampal and cerebellar cortices [66,67]. This evidence concerns the gene PAFAH1B1 and lissencephaly spectrum disorders.