At the molecular level, the most compromised signaling pathways are linked to the altered activity of oncogenes, such as Myc (avian myelocytomatosis viral oncogene homolog) and tumor suppressors genes (Rb (retinoblastoma protein) and p53), which are functionally inactivated in most cases of osteosarcoma [11]. Here, RB1 is linked to osteosarcoma.