As the frequent IDH1/2 mutation induces global DNA hypermethylation, commonly known as glioma CpG island methylator phenotype (G-CIMP) in LGG [6], in this study, we first investigated the correlation between PODNL1 methylation and PODNL1 mRNA expression in TCGA-LGG to determine whether PODNL1 expression is epigenetically regulated, and identified specific methylated CpG islands that significantly correlate with PODNL1 mRNA expression. The gene discussed is PODNL1; the disease is glioma.