As the frequent IDH1/2 mutation induces global DNA hypermethylation, commonly known as glioma CpG island methylator phenotype (G-CIMP) in LGG [6], in this study, we first investigated the correlation between PODNL1 methylation and PODNL1 mRNA expression in TCGA-LGG to determine whether PODNL1 expression is epigenetically regulated, and identified specific methylated CpG islands that significantly correlate with PODNL1 mRNA expression. Here, PODNL1 is linked to central nervous system cancer.