As DFS indicates tumor aggressiveness through faster recurrence, we firstly analyzed the prognostic effects of PODNL1 mRNA in the DFS of all TCGA cancers (Figure 2A), where PODNL1 mRNA overexpression was associated with significantly unfavorable DFS in four TCGA cancers including ACC, KIRC, KIRP, and LGG. Here, PODNL1 is linked to adrenal cortex carcinoma.