IDH1 and neoplasm: As we found a significant association between methylation of PODNL1 CpG sites and mRNA expression, we investigated whether the methylation of these particular CpGs affects the PODNL1 prognostic effects, and performed univariate and multivariate survival analysis (DFS and OS) adjusting for patient age, gender, tumor grade, and IDH1 mutation status (Table 1).