A comprehensive survival analysis revealed four PODNL1 CpGs (cg07425555, cg26969888, cg18547299, and cg24354933) that were significant independent prognostic factors for both OS and DFS in multivariate analysis (adjusted for age, gender, tumor grade, and IDH1 mutation status), where low methylation levels were associated with a more unfavorable clinical outcome. The gene discussed is PODNL1; the disease is neoplasm.