Altogether, terpene/terpenoids displayed auspicious anti-PD effects by targeting mitochondria, thereby suppressing complex I–III activity, PINK1/parkin, ROS, Bax, JNK/p38MAPK, IKK/NF-κB, VDAC1, PI3K/Akt/GSK-3β, and IL-6/STAT3/NF-κB. Here, MAPK8 is linked to Parkinson disease.