A combined assessment of the expression of Ki-67 and p16ink4a biomarkers in combination with H&E staining was used to objectify the differential diagnosis of CIN1-CIN3 intraepithelial neoplasms, and E4 and hypermethylation in the epithelial cells of the cervix were proposed as potential biomarkers of cervical cancer [30]. Here, MKI67 is linked to intraepithelial neoplasia.