A meta-analysis (7 articles, 2628 patients) assessing the accuracy of double immunocytochemical staining of p16/Ki-67 testing for high-risk HPV demonstrated that this diagnostic test is characterized by high sensitivity and moderate specificity in the study of PAP smears with abnormalities for HSIL and cervical carcinoma [29]. This evidence concerns the gene CDKN2A and cervical carcinoma.