Numerous biomarkers have been investigated in CIN and cervical cancer; the correlation between HPV infection and overexpression of commonly used biomarkers, such as p53 and bcl2, has not always been established in all cases, as there is no significant relationship between HPV 16/18 infection and p53 and bcl2 expression in precancerous and malignant lesions. This evidence concerns the gene BCL2 and cervical cancer.