The results of a study of cervical squamous cell carcinoma tissues indicate that the main contribution to the invasive and metastatic potential is made by an increase in the expression of collagenases—MMP-1 and MMP-14 and gelatinase–MMP-9 as well as a decrease in the expression of inhibitors—TIMP-1 and TIMP-2 and to a less extent, increases in the expression of MMP-2, MMP-1, and MMP-9 can serve as markers for the development of invasive and metastatic potential in squamous cell carcinoma of the cervix. This evidence concerns the gene MMP14 and squamous cell carcinoma.