The data obtained during a study of the role of the deletion at locus 4 of pancreatic carcinoma (DPC4) and vascular endothelial growth factor (VEGF) in the development of cervical cancer suggest that the loss of DPC4 and overexpression of VEGF may play an important role in the progression of cervical carcinoma. Here, SMAD4 is linked to exocrine pancreatic carcinoma.