It has been described that CaM-kinase-like 1 (DCAMKL-1), Lgr5, CD133, α-fetoprotein, cytokeratin-9 (CK19), Lin28, and c-Myc are activated in hepatocellular carcinoma cancer stem cells (CSCs); DCAMKL-1 may be a specific marker of CSCs [48]. This evidence concerns the gene PROM1 and cancer.