A meta-analysis of studies of double immunocytochemical staining of cytological smears with p16/Ki-67 demonstrated that this test is characterized by a high level of sensitivity and moderate specificity for detecting squamous cell intraepithelial lesions and cervical cancer, i.e., p16/Ki-67 double staining may be a reliable adjunct method for detecting high-grade squamous intraepithelial lesions (HSIL) in pathology in women by PAP testing. Here, CDKN2A is linked to squamous cell intraepithelial neoplasia.