The main biomarkers associated with the cell cycle, proliferation, and apoptosis in cervical neoplasms include Ki-67, cyclin-dependent kinases and their inhibitors, surrogate marker of HPV infection p16INK4a which is associated with active expression of HPV E7), pRb protein, p53 gene products, anti-apoptotic protein BCL-2, and pro-apoptotic protein BAX. The gene discussed is CDKN2A; the disease is uterine cervix neoplasm.