It was found that there is a gradual decrease in E-cad expression and an increase in P-cad during the development from CIN to cervical squamous cell carcinoma, the expression of cadherins or E-P switching was associated with some clinical parameters indicating poor prognosis and patient survival, and immunohistochemical staining to detect E-cad and P-cad is useful in the diagnosis of CIN and the prognosis of disease at an early stage of cervical cancer [50]. The gene discussed is CDH3; the disease is cervical squamous cell carcinoma.