Moreover, tumour-derived exosomes loaded with ADO, inosine, and CD39/CD73 could travel to distant tumour sites where they could trigger endothelial cell growth and polarization of macrophages towards an M2-like phenotype via activation of A2BR. In this way, they would simultaneously directly and indirectly promote angiogenesis [142]. The gene discussed is ENTPD1; the disease is neoplasm.