In endothelial progenitor cells (EPC), expression of the C-X-C motif chemokine receptor 4 (CXCR4) is upregulated after ADO treatment, and ADO can subsequently increase EPC migration to the heart after myocardial infarction where it stimulates angiogenesis via A2BR and CXCR4-dependent mechanisms [102]. Here, CXCR4 is linked to myocardial infarction.