PTGS2 and renal cell adenocarcinoma: More recently, an ADO gene signature (AdenoSig) was identified in patients with renal cell cancer, consisting of immune-related genes encoding interleukin 1β (IL-1β), prostaglandin-endoperoxide synthase 2 (PTGS2), and C-X-C motif chemokine ligand 1 (CXCL1), 2, 3, 5, 6, 8 [46].