In another newly published study, Yun Ge et al. conducted a murine-based study aimed at investigating the immunobiological roles of IL-38 in immune responses mediated by CD4+ CD25+ Tregs were involved in the immunopathophisiology of sepsis and they reported remarkably enhanced immunosuppressive activities of the mentioned cells by IL-38 [209]. This evidence concerns the gene IL1F10 and Sepsis.