Furthermore, the PAI-2 variant rs8093048 was associated with coronary artery disease in Chinese Han population (a total of 925 individuals participated in this study: 407 patients with coronary artery disease and 518 healthy controls) [141], while Ser(413)/Cys (rs6104) failed to show an association with premature coronary artery disease in a smaller study of southern Iran population (200 patients and 200 control subjects participated in this study) [142]. Here, SERPINB2 is linked to coronary artery disorder.