HSPA5 and amyotrophic lateral sclerosis: Our data showed that the response was different in ALS (greater vulnerability) compared to PD (no differences), which may indicate differences in the role played by BiP in relation with its canonical functions (i.e., control of protein folding and assembly, endoplasmic reticulum stress response) and, eventually, with CB1 receptor signaling in those neuronal subpopulations present in the CNS structures affected in both disorders.