A biological relationship between EGFR, MET, and the miRNA cluster 23a∼27a∼24–2 was unveiled, where miR-27a regulated MET, EGFR, and Sprouty2 in a panel of NSCLC cell lines (293, 293TN, H460, A549, H1299). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.