The signaling pathway of EGFR activates intracellular signaling cascades, including Signal Transducer and Activator of Transcription (STAT), Rat Sarcoma/Rapidly Accelerated Fibrosarcoma/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase 1/2 (Ras/Raf/MEK/ERK1/2), phospholipase C (PLC)/protein kinase C (PKC), and phosphoinositide 3-kinase/phosphoinositide 3-kinase/Protein kinase B (PI3K/Akt) pathways that boost angiogenesis, tumor cell proliferation, metastasis, invasion, and apoptosis evasion [10,12,13,14,15,16] (Figure 1). This evidence concerns the gene MAPK3 and neoplasm.