Moreover, sperm-associated antigen 5 (SPAG5), an important target gene of miR-133a-3p, reversed the miR-133a-3p-mediated sensitivity of NSCLC cells to gefitinib, implying that the miR-133a-3p/SPAG5 axis played a key role in acquired resistance to gefitinib in NSCLC cells [225]. The gene discussed is SPAG5; the disease is non-small cell lung carcinoma.