First described in colon cancer, CCAT1 and CCAT2 both originate from the 8q24.21 chromosomal region, in close proximity with the MYC gene (500 kb and 300 kb upstream, respectively) and encompassing the cancer risk-associated rs6983267 single nucleotide polymorphism (SNP) (Figure 1) [16,17,18]. This evidence concerns the gene CCAT2 and colonic neoplasm.