SIRT1 and neoplasm: Analyses of age-associated cutaneous miRNAs in keratinocytes by Rivetti et al. [113] showed increased expression of miR-130, miR-138, and miR-181a/b during replicative senescence; these processes target the p63 (a member of the p53 superfamily involved in epidermal development and tumor regulation) and sirtuin 1 (SIRT1) (a NAD-dependent histone deacetylase involved in cellular differentiation, metabolism, immune response, and apoptosis) mRNAs.