In this study, we investigated the changes in the expression and intracellular localization of DNA methyltransferase DNMT1, histone methyltransferases SUV39H1 and G9a in penumbra neurons and astrocytes in penumbra nuclear and penumbra cytoplasmic fractions at 4 and 24 h after photothrombotic stroke (PTS). The gene discussed is EHMT2; the disease is stroke disorder.