About 60 Single Nucleotide Polymorphisms (SNPs) are present on the NLRP3 gene and the five most studied in SLE are rs10754558, rs4612666, rs3806268, rs35829419, and rs4352135, due to Minor Frequency Allele (MAF) and/or possible functional impact. Here, NLRP3 is linked to systemic lupus erythematosus.