However, two SNPs are more associated with SLE: rs35829419 (C > A) is a missense variant with gain-of-function with overexpression of IL-1β and IL-18 and rs10754558 (C > G) located in 3′UTR gene region, in which the C allele decreases the stability of mRNA in relation to the G allele and consequently IL-1β and IL-18 cytokines secretion [31,32]. This evidence concerns the gene IL18 and systemic lupus erythematosus.