One study showed that EGCG was able to prevent the development of LN in NZB/WF1 lupus-prone mice due to inactivation of the Nrf2 antioxidant pathway, which resulted in renal NLRP3 inflammasome inactivation with less amounts of IL-1β and IL-18 in kidney lysates. Here, NLRP3 is linked to systemic lupus erythematosus.