IL18 and viral infectious disease: Metascape analysis showed that the top overlapping genes are involved in the response to viral infection (regulation of viral life cycle, viral entry into host cell, response to virus, response to interferon-gamma, and RNA degradation); antigen processing and presentation; P2X7 receptor signaling complex, which senses ATP released by dying cells and plays a role in inflammation; IL-18 signaling; and apoptotic signaling (Table 3, Supplemental File 3).