Top Metascape enriched biological categories affected by chemical exposures are involved in the regulation of protein synthesis and processing (ribosome, protein folding, protein processing in endoplasmic reticulum, and others), immune response (cytokine signaling, VEGFA-VEGFR2 signaling, leukocyte activation, and response to viral infection), response to stress (response to toxic substance, transcriptional regulation by TP53, and regulation of cellular stress response), and apoptosis (Table 1, Supplemental File 2). The gene discussed is TP53; the disease is viral infectious disease.