In contrast, LBs inclusions found in PD differ considerably from those observed in AATD and HHHS, as LBs are constituted by several different proteins and can be found in different organelles and structures of the adult brain, whereas AAT and fibrinogen inclusions are restricted to the ER of hepatocytes and can be initiated during childhood. The gene discussed is SERPINA1; the disease is alpha 1-antitrypsin deficiency.