IFNB1 and infection: The recent HSV-1 study of Uyar et al. showed that transient and incomplete depletion of microglia during early stage of infection decreased the brain levels of IFN-β mRNA and infiltrating monocytes/macrophages, neutrophils, and T cells [23] in manners contrast to our study with long term and efficient microglia depletion via PLX 5622 before and during the entire infection period.