ALB and obesity due to melanocortin 4 receptor deficiency: We suggest disturbed mineral homeostasis (in particular reduced albumin, increased ionised calcium, and elevated serum CPP formation propensity) as an additional risk factor of cardiovascular disease, although its contribution might be less significant in comparison with other major established cardiovascular risk factors (i.e., dyslipidaemia, arterial hypertension, overweight/obesity, and carbohydrate metabolism disorders), in concert with the epidemiological studies that showed an association between increased calcium, decreased albumin, and major adverse cardiovascular events [1,2,3,4].