Interestingly, K14 haploinsufficiency also causes two heritable diseases: Naegeli–Franceschetti–Jadassohn Syndrome and Dermatopathia pigmentosa reticularis, accompanied by the apoptotic death of basal KCs, hyperkeratosis, palmoplantar keratoderma, and other generalized manifestations. The gene discussed is KRT14; the disease is dry eye syndrome.