Apart from the most common causes of KRT5 and KRT14 mutations, which have already been mentioned, EBS could be induced by mutations in the other genes, such as Dystonin (DST), Plectin (PLEC), Exophilin 5 (EXPH5), Kelch-like member 24 ( KLHL24), and CD151 antigen (CD151) [44]. The gene discussed is PLEC; the disease is epidermolysis bullosa simplex.