Similar to what we found in Original Braunvieh cattle, the CNGB3 missense mutation causing achromatopsia in German shorthaired pointers is also located in exon 6 (c.784G, p.Asp262Asn), affecting the corresponding residue of a conserved region of the same gene, suggesting an important role for this aspartate residue in channel biogenesis and/or function [21]. This evidence concerns the gene CNGB3 and achromatopsia.