PRNP and infection: We have recently reported that infection of mouse neuroblastoma N2a cells overexpressing the exogenously transduced mouse PrPC, termed N2aC24 cells, with a neurotropic strain of influenza A/WSN/33 (H1N1) virus (hereafter referred to as IAV/WSN) induced spontaneous conformational changes in PrPC to form PrPSc-like PK-resistant PrP [24].