TGFB1 and neoplasm: Moreover, MSCs injected 14 days after tumor induction induced the generation of an immunosuppressive phenotype in CD4+T lymphocytes and prevented the trans-differentiation of TGF-β and IL-10-producing Tregs into anti-tumorigenic IFN-γ- and IL-17-producing Th1 and Th17 cells [32].