Irradiated BM-MSC1 secretes a large amount of TNF-α and IFN-γ, which: (i) inhibit the proliferation of tumor cells by deregulating Wnt and TGF-β/Smad signaling and (ii) induce the apoptosis of tumor cells by blocking their cell cycle in the G1 phase. Here, TGFB1 is linked to neoplasm.