CD4+Th cells orchestrate the anti-tumor immune response through the production of interleukin (IL)-2, which increases the proliferation of CD8+ CTLs and through the secretion of interferon gamma (IFN-γ), which induces the generation of the anti-tumorigenic M1 phenotype in tumor-infiltrated macrophages (TAMs) [1,3]. This evidence concerns the gene CD8A and neoplasm.