Our data on the sequential time course of 13 melanoma patients (effectively, as reported, 15 time-course analyses), showed that the two distinct CMC subpopulations, “endothelial” and “hybrid stem–mesenchymal” fractions, expressed CD146 isoforms long, short, or 5′-portion at first observation (from 37.5% to 100%) and at disease progression (100%). Here, MCAM is linked to melanoma.