By administering CXCR2 inhibitor (SB225002) or Oil preventively to CCl4-treated mice, we found that SB225002 significantly weakened liver injury and attenuated CCl4-induced liver fibrosis by H&E staining (Figure 7A) and Sirius Red staining (Figure 7B,C). The gene discussed is CXCR2; the disease is Hepatic fibrosis.