Overall, the results obtained in the bleomycin-induced mouse model of skin fibrosis are in line with those previously reported in human SSc [31,32] and, hence, they suggest that the progressive reduction in the network of TCs/CD34+ stromal cells might contribute to dermal tissue remodeling by favoring an uncontrolled synthetic activity of fibroblasts and, possibly, their transition to profibrotic myofibroblasts. Here, CD34 is linked to systemic sclerosis.